Research on guayule rubber has been conducted for almost a century now, since leaf blight wiped out the natural rubber industry in South America. While industrialists such as Harvey Firestone, Henry Ford and Andrew Carnegie labored to restart the commercial rubber plantations in South America without success, a few others looked into domestic alternatives. Early work focused on indigenous species of guayule found in the desert southwest of the U.S. and northern Mexico. Prior to amassing his great fortune in steel, Andrew Carnegie once lamented, “I should have chosen rubber.”